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KMID : 0361520070180050271
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Korean Journal of Psychopharmacology
2007 Volume.18 No. 5 p.271 ~ p.279
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Role of 5-HT1A Receptors in Learning and Memory
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Kim Ji-Woong
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Abstract
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Growing evidence indicates that the serotonin system is important in learning and memory. In particular, several preclinical and clinical studies suggest that modulating the 5-HT1A receptor can influence learning and memory, and indeed, it has been observed that presynaptic 5-HT1A receptor agonists and postsynaptic 5-HT1A receptor antagonists tend to ameliorate the learning/memory impairment induced by various methods. In contrast, postsynaptic 5-HT1A receptor agonists tend to decrease the learning/memory function. These observations suggest the possibility that modulating neurotransmission mediated by the 5-HT1A receptor may be effective as a therapeutic strategy for enhancing learning and memory in various neuropsychiatric disorders. Unfortunately, there is no available discussion on the relationship between 5-HT1A receptor and learning/memory in Korea. This article reviews the clinical or preclinical literature on this issue.
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KEYWORD
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5-HT1A receptor, Learning·Memory
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